论文部分内容阅读
变应性鼻炎是一种常见的过敏性疾病,鼻用糖皮质激素作为一线用药用于变应性鼻炎的临床治疗。然而患者的激素治疗效果存在显著个体差异,部分患者激素治疗无效,称为激素抵抗性变应性鼻炎。随着“变应性鼻炎-哮喘综合征”“一个气道、一种炎症”等概念的提出,很多研究者认为影响吸入用糖皮质激素治疗效果的基因会对鼻用糖皮质激素的疗效产生影响。糖皮质激素相关的基因多态性是导致激素抵抗的重要因素,本文综述糖皮质激素药物基因组学的相关研究,期待能为基因检测指导的变应性鼻炎糖皮质激素个体化治疗提供证据支持。
Allergic rhinitis is a common allergic disease, nasal glucocorticoid as first-line medication for the clinical treatment of allergic rhinitis. However, the patient’s hormone therapy there are significant individual differences, some patients with hormone therapy is invalid, known as hormone-resistant allergic rhinitis. With the concept of “allergic rhinitis-asthma syndrome” and “an airway, an inflammation,” many researchers believe that the genes that affect the therapeutic effect of inhaled glucocorticoid may have effects on nasal glucocorticoids Hormonal effects have an impact. Glucocorticoid-related gene polymorphism is an important factor leading to hormone resistance. This review summarizes the research on glucocorticoid drug genomics and is expected to provide evidence for the personalized detection of glucocorticoid allergic rhinitis guided by genetic testing.