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细胞激活剂肉豆蔻酰佛波醇乙酯 (ＰＭＡ)是蛋白激酶Ｃ(ＰＫＣ)的特异性激动剂 ,ＰＭＡ具有促进Ｕ937细胞和ＨＬ - 60细胞分化的作用 ,能使Ｕ937细胞和ＨＬ - 60细胞膜上的整合素 β2 亚族ＣＤ1 8蛋白增多。但ＰＭＡ诱导作用的机制尚未明了。目的 :进一步阐明ＰＭＡ促进ＣＤ1 8?
PMA, a specific agonist of protein kinase C (PKC), can promote the differentiation of U937 cells and HL - 60 cells, and can make U937 cells and HL - 60 cell membrane On the integrin β2 subfamily CD18 protein increased. However, the mechanism of the induction of PMA is unclear. PURPOSE: To further elucidate PMA-promoted CD1 8?