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目的:探讨激活素A和抑制素A与晚期流产及绒毛膜羊膜炎的关系。方法:选择90例孕周在13～19周孕妇,其中正常妊娠组40例,稽留流产组36例,难免流产22例。3组年龄、孕周、孕产次无差异,测定激活素A与抑制素A血清浓度,并取胎膜做病理检查。结果:稽留流产组、难免流产组激活素A/抑制素A水平低于正常妊娠组(P<0.01);两组绒毛膜羊膜炎发生率明显高于正常妊娠组。绒毛膜羊膜炎组激活素A浓度高于非绒毛膜羊膜炎组(P<0.01);绒毛膜羊膜炎组抑制素A水平与非绒毛膜羊膜炎组相比,差异无显著性(P>0.05)。结论:血清激活素A和抑制素A对难免流产及稽留流产的诊断和预测具有一定的价值;激活素与绒毛膜羊膜炎密切相关,可为临床诊断和预测亚临床绒毛膜羊膜炎提供依据。
Objective: To investigate the relationship between activin A and inhibin A in patients with advanced abortion and chorioamnionitis. Methods: 90 pregnant women with gestational age of 13 to 19 weeks were enrolled. Among them, 40 were normal pregnancy group and 36 were missed abortion group, 22 were inevitable abortion. Three groups of age, gestational age, no difference in gestational age, determination of activin A and inhibin A serum concentration, and fetal membranes for pathological examination. Results: In missed abortion group, the level of activin A / inhibin A in patients with unreliable abortion was lower than that in normal pregnancy group (P <0.01). The incidence of chorioamnion in two groups was significantly higher than that in normal pregnancy group. The concentration of activin-A in chorioamnionitis group was higher than that in non-chorioamnionitis group (P <0.01). There was no significant difference of inhibin A level between chorioamnionitis group and non-chorioamnionitis group (P> 0.05 ). CONCLUSION: Serum activin A and inhibin A are valuable for the diagnosis and prediction of abortion and missed abortion. Activin is closely related to chorioamnionitis, which may provide evidence for clinical diagnosis and prediction of subclinical chorioamnionitis.