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在湖南省衡山县对常用驱虫药的疗效进行了研究。所用药物为阿苯达唑(400mg,单剂)、复方甲苯达唑(甲苯达唑100mg和左旋咪唑25mg bid×3d)、复方噻嘧啶(噻嘧啶与酚嘧啶各150mg,bid×2d)及噻嘧啶(10mg基质/kg,单剂)。给药后2wk的疗效显示前3种药物剂量组蛔虫感染者治愈率(CR)为97.5—100.0％,后者为80.9％;对钩虫感染者的CR分别为95.4％、78.6—100％、96.7％和83.3％,服药后4wk复查显示上述4个药物剂量组的CR无显著性差异。根据对鞭虫感染的CR来判断,以复方噻嘧啶为佳(89.3％),其次为复方甲苯达唑(64.6—83.8％),阿苯达唑再次之(28.2—42.6％),噻嘧啶无效。上述药物除噻嘧啶外,治疗鞭虫感染时虫卵减少率均显著。
In Hengshan County, Hunan Province, the efficacy of commonly used deworming drugs was studied. The drugs used were albendazole (400mg, single dose), compound mebendazole (mebendazole 100mg and levamisole 25mg bid × 3d), compound pyrantel (pyrimethamine and pyrimethamine 150mg, bid × 2d) and thiophene Pyrimidine (10 mg substrate / kg, single dose). The efficacy of 2 weeks after administration showed that the cure rate (CR) of ascaris infection was 97.5-100.0% and the latter was 80.9% in the first 3 kinds of drug dosage groups. The CR of hookworm infected patients were 95.4%, 78.6-100% and 96.7 % And 83.3%, 4wk after taking the drug review showed that the above four drug dose group CR no significant difference. According to CR of whipworm infection, compound pyrantel was the best (89.3%), followed by compound mebendazole (64.6-83.8%), albendazole (28.2-42.6%) again, pyrantel was ineffective . In addition to pyrimidine pyrimidine drug treatment, the treatment of whipworm infection reduction of eggs were significant.