论文部分内容阅读
本实验通过荧光分光、放射免疫方法研究了5—羟色胺(5—HT),氧合血红蛋白(OXYHb)致血管痉挛后,前列环素(PGI_2)、血栓烷(TX)A_2、前列腺素(PG)E_2、过氧化脂质(LPO)的变化。5—HT作用于基底动脉与股动脉,均引起重度痉挛(+++),动脉壁6—酮—PGF_(1α)、TXB_2、PGE_2、LPO均无变化(P>0.05)。OXYHb产生基底动脉重度痉挛(+++),6—酮—PGF_(1α)明显减少(P<0.01)、LPO明显升高。OXYHb不产生股动脉收缩。动脉壁PG无变化(P>0.05),LPO明显升高(P<0.01)。提示:5—HT与OXYHb产生血管痊挛的机制不同。
In this study, we investigated the effects of 5-HT and OXYHb on PGI-2, PG-2, E_2, lipid peroxidation (LPO) changes. 5-HT on the basilar artery and femoral artery all caused severe spasticity (+++), arterial wall 6-keto-PGF_ (1α), TXB_2, PGE_2 and LPO had no change (P> 0.05). OXYHb produced severe basilar artery spasm (+++), 6-keto-PGF_ (1α) decreased significantly (P <0.01), LPO increased significantly. OXYHb does not produce femoral artery contractions. Arterial wall PG did not change (P> 0.05), LPO was significantly higher (P <0.01). Tip: 5-HT and OXYHb have different mechanisms of vascular revascularization.