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[目的]探讨硝普钠联合多巴胺在重症充血性心力衰竭治疗中的临床疗效。[方法]81例重症充血性心力衰竭患者,在吸氧、强心剂、利尿剂等常规治疗方法的基础上,随机分为两组,硝普钠联合多巴胺组(观察组)42例,多巴胺应用组(对照组)39例,治疗前后患者评估两组疗效,超声心动图检查心率、心脏收缩压、舒张压、LVDS及LVDD等心功能指标变化。[结果]硝普钠并多巴胺观察组显效、总有效率分别为64.3%、90.5%,显著高于对照组(P﹤0.05);联合用药组治疗后,各心功能指标均得到显著改善,与治疗前相比,具有极显著性差异(P﹤0.01)。[结论]硝普钠联合多巴胺治疗重症充血性心力衰竭具有一定的协同效果,可改善心肌收缩能力,减轻心脏负荷,且不会增加副作用,具有较好应用前景。
[Objective] To explore the clinical effect of sodium nitroprusside combined with dopamine in the treatment of severe congestive heart failure. [Methods] 81 patients with severe congestive heart failure were randomly divided into two groups: 42 patients in the observation group, sodium nitroprusside plus dopamine group (observation group), and the conventional dopamine treatment group (Control group). 39 patients were evaluated before and after treatment. Echocardiography was used to evaluate heart function, cardiac systolic pressure, diastolic blood pressure, LVDS and LVDD. [Results] The SNP and Dopamine groups were significantly effective and the total effective rates were 64.3% and 90.5%, respectively, significantly higher than those in the control group (P <0.05). After treatment, the cardiac function indexes of the combination group were significantly improved, and Compared with before treatment, with a significant difference (P <0.01). [Conclusion] Sodium nitroprusside combined with dopamine has synergistic effect in the treatment of severe congestive heart failure. It can improve myocardial contractility, reduce cardiac load, and will not increase the side effects. It has a good prospect of application.