白介素(IL)-13是近年来新克隆的Th2型细胞因子,可通过募集、归巢、激活炎性细胞介导嗜酸粒细胞(EOS)的聚集和气道高反应性(AHR)。Eotaxin是CC趋化因子家族成员之一,是唯一与CCR3受体特异性结合的趋化因子,可以促进EOS在气道的募集与活化。IL-13促进Eotaxin在肺组织产生,IL-13和Eotaxin起协同作用提高EOS在肺组织聚集,在哮喘气道炎症的发生中起重要作用。最近研究认为通过阻断IL-13和Eotaxin的产生,可能成为治疗哮喘的新方法。 Interleukin-13 (IL-13) is a newly cloned Th2 cytokine that mediates eosinophil (EOS) aggregation and airway hyperresponsiveness (AHR) through recruitment, homing and activation of inflammatory cells. Eotaxin, a member of the CC chemokine family, is the only chemokine that specifically binds to the CCR3 receptor and promotes EOS recruitment and activation in the airways. IL-13 promotes the production of Eotaxin in the lung tissue. The synergistic effect of IL-13 and Eotaxin increases the accumulation of EOS in the lung tissue and plays an important role in the pathogenesis of airway inflammation in asthma. Recent studies suggest that by blocking the production of IL-13 and Eotaxin, may become a new method of treatment of asthma.