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[目的]评估叶绿酸能否降低肝癌高危人群尿中黄曲霉毒素(AFT)鄄N7鄄鸟嘌呤的水平。[方法]采用随机双盲、以安慰剂为对照的预防干预试验。将180名健康成人随机分成叶绿酸干预组(服用100mg叶绿酸)和安慰剂对照组。采用顺序免疫亲和色谱法和液相色谱法结合电子喷射质谱法测定尿中AFT鄄N7鄄鸟嘌呤的变化。[结果]在169份尿样中,105份检出AFT鄄N7鄄鸟嘌呤。叶绿酸组尿中AFT鄄N7鄄鸟嘌呤比安慰剂组下降了55%(P=0.036)。未见副作用。[结论]应用叶绿酸或富含叶绿素的食物进行预防干预是可能阻断肝癌的有效手段。
[Objective] To evaluate whether chlorophyllin can reduce the level of aflatoxins (AFT) -N7-Guanine in high-risk liver cancer patients. [Methods] A randomized, double-blind, placebo-controlled trial of preventive intervention was used. 180 healthy adults were randomly divided into the chlorophyllin intervention group (taking 100 mg chlorophyllin) and the placebo control group. Sequential immunoaffinity chromatography and liquid chromatography combined with electron spray mass spectrometry were used to determine the changes of AFT-N7-guanine in urine. [Results] Among 169 urine samples, 105 samples were detected AFT-N7-guanine. AFT-N7-guanine in the chlorogenic acid group was 55% less in the urine than in the placebo group (P = 0.036). No side effects. [Conclusion] Preventative intervention with chlorogenic acid or chlorophyll-rich food is an effective way to block the liver cancer.