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目的探讨抗病毒治疗对乙肝肝硬化患者血清甲状腺激素的影响。方法选取乙肝肝硬化患者80例(肝硬化组),对照组为同期健康体检人群40例。肝硬化组接受恩替卡韦抗病毒治疗。根据肝硬化患者治疗后乙型肝炎病毒(HBV)DNA是否转阴分为转阴组56例,未转阴组24例,观察患者治疗前后血清甲状腺激素水平及肝功能指标。结果治疗前,肝硬化组血清三碘甲状腺原氨酸(T3)、游离三碘甲状腺原氨酸(FT3)、甲状腺素4(T4)、游离甲状腺素(FT4)低于对照组(P<0.05),促甲状腺激素(TSH)高于对照组(P<0.05)。治疗后,肝硬化组患者总胆红素(TBil)、丙氨酸氨基转移酶(ALT)、谷氨酸氨基转移酶(AST)降低,白蛋白(Alb)提高(P<0.05);HBV DNA转阴组T3、FT3、T4、FT4高于未转阴组(P<0.05),TSH低于未转阴组(P<0.05)。结论抗病毒治疗可以有效改善乙肝肝硬化患者血清甲状腺激素水平的紊乱失衡状态。
Objective To investigate the effect of antiviral therapy on serum thyroid hormones in patients with hepatitis B cirrhosis. Methods Eighty patients with cirrhosis (cirrhosis) were enrolled in the study. Forty patients in the control group were enrolled in the same period. The cirrhosis group received antiviral therapy with entecavir. According to the patients with cirrhosis after treatment of hepatitis B virus (HBV) DNA is negative or negative, divided into negative group of 56 cases, 24 cases of non-negative group, observed before and after treatment of patients with serum thyroid hormone levels and liver function indicators. Results Before treatment, the levels of serum triiodothyronine (T3), free triiodothyronine (FT3), thyroxine 4 (T4) and free thyroxine (FT4) in cirrhosis group were lower than those in control group (P <0.05 ), Thyroid stimulating hormone (TSH) than the control group (P <0.05). After treatment, the levels of total bilirubin (TBil), alanine aminotransferase (ALT) and glutamate aminotransferase (AST) and albumin (Alb) in patients with cirrhosis decreased (P <0.05) T3, FT3, T4, FT4 in the negative group were significantly higher than those in the negative group (P <0.05), while those in the negative group were lower than those in the negative group (P <0.05). Conclusion Antiviral therapy can effectively improve the imbalance of serum thyroid hormone levels in patients with hepatitis B cirrhosis.