肥胖是胰岛素抵抗和2型糖尿病的主要危险因素。脂肪细胞分泌的多种物质与胰岛素的敏感性可能相关。本文简单介绍了与肥胖性胰岛素抵抗相关的物质leptin、TNF、Acrp30、IL-6。在研究抗糖尿病新药TZDs作用机制时发现的脂肪组织特异性分泌蛋白-Resistin(胰岛素抗性蛋白),在肥胖症中,其含量升高,它具有调节血糖平衡、拮抗胰岛素的作用。Resistin可能是肥胖与糖尿病之间的连接点。Resistin的作用有待于进一步的研究。 Obesity is a major risk factor for insulin resistance and type 2 diabetes. A variety of substances secreted by adipocytes may be associated with insulin sensitivity. This article provides an overview of leptin, TNF, Acrp30, and IL-6, a substance involved in obesity. In the study of anti-diabetic drug TZDs mechanism of action found in adipose tissue-specific secreted protein - Resistin (insulin resistance protein), in obesity, its content increased, it has to regulate blood sugar balance, antagonism of insulin. Resistin may be the connection point between obesity and diabetes. The role of Resistin remains to be further studied.