论文部分内容阅读
目的探讨缬沙坦和左旋氨氯地平单独和联合应用治疗高血压的降压效果及对肾功能的保护作用。方法90例原发性高血压伴微量清蛋白尿患者随机分为缬沙坦治疗组、左旋氨氯地平治疗组和联合治疗组各30例,3组分别给予缬沙坦80mg,左旋氨氯地平2.5mg,缬沙坦80mg+左旋氨氯地平2.5mg,口服,1/d,若2周后血压未降至正常,则缬沙坦增至160mg,左旋氨氯地平增至5mg。疗程均为24周。观察治疗前后血压和肾功能变化。结果3组患者血压均明显下降(均P<0.01),尿微量清蛋白、β2微球蛋白均显著降低(P<0.01)。联合用药组降压和降尿蛋白作用优于二单独用药组(均P<0.01)。结论缬沙坦、左旋氨氯地平治疗原发性高血压均有较好的降压作用,且能降低微量清蛋白和微球蛋白,降低新发肾功能损害,两药联合应用可起到协同作用,更有效地降低血压,改善早期肾功能损害指标。
Objective To investigate the antihypertensive effect of valsartan and levamlodipine alone and in combination on hypertension and its protective effect on renal function. Methods Ninety patients with essential hypertension with microalbuminuria were randomly divided into valsartan treatment group, levamlodipine treatment group and combination therapy group, 30 cases each. The three groups were given valsartan 80 mg, levamlodipine 2.5mg, valsartan 80mg + levamlodipine 2.5mg, orally, 1 / d, if 2 weeks after the blood pressure did not fall to normal, valsartan increased to 160mg, levamlodipine increased to 5mg. The course of treatment was 24 weeks. Before and after treatment to observe the changes in blood pressure and renal function. Results The blood pressure of the three groups were significantly decreased (all P <0.01), urinary albumin and β2 microglobulin were significantly decreased (P <0.01). The effect of lowering blood pressure and reducing protein in combination group was better than those in two groups (all P <0.01). Conclusion Valsartan and L-amlodipine have a good antihypertensive effect in treating essential hypertension, and can reduce the content of albumin and microglobulin and reduce the damage of new-onset renal function. The combination of the two drugs can play a synergistic effect Role, more effective in lowering blood pressure, improve the indicators of early renal damage.