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1.肝脏酒精代谢产物损伤:(1)乙醛的化学性损害:机体摄入的酒精90％以上在肝脏代谢,经过乙醇脱氢酶、肝微粒体乙醇氧化酶系统和过氧化氢酶氧化成乙醛,乙醛可损害各种细胞器和酶的结构功能;又能刺激免疫系统,诱发免疫反应性肝损害;损害线粒体脂肪酸的β氧化,引起脂质过氧化反应,抑制谷胱甘肽(GSH)的生物合成,减弱超过氧化物酶等抗氧化功能。(2)氧化还原反应的改变:酒精氧化引起氧化型的辅酶Ⅰ
1. Liver alcohol metabolites damage: (1) chemical damage of acetaldehyde: more than 90% of the body intake of alcohol in the liver metabolism, after alcohol dehydrogenase, liver microsomal ethanol oxidase system and catalase oxidation Acetaldehyde and acetaldehyde can damage the structure and function of various organelles and enzymes, stimulate the immune system and induce immune-reactive liver damage, impair β-oxidation of mitochondrial fatty acids, cause lipid peroxidation and inhibit glutathione (GSH ) Biosynthesis, weakened more than antioxidant enzymes such as oxidative function. (2) changes in the redox reaction: alcohol oxidized oxidized coenzyme Ⅰ