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为了解谷胱甘肽Ｓ－转移酶（ＧＳＴ）在癌变过程中的作用及对肝癌是否有早期诊断价值，以化学致癌剂２－乙酰氨基芴（２－ＦＡＡ）诱导大鼠肝癌，检测其癌变过程中血清ＧＳＴ活性的动态变化。结果显示：大鼠摄入２－ＦＡＡ２周后，血清ＧＳＴ活性比正常对照组明显升高（Ｐ＜０．０５）；第４周时，ＧＳＴ活性比正常对照组升高４倍以上（Ｐ＜０．０１），达到高峰值；以后ＧＳＴ活性逐步缓慢下降，到１０周以后趋于正常水平。研究表明，ＧＳＴ是癌变早期的标志酶，血清ＧＳＴ活性检测对肝癌的早期诊断有一定的价值。
In order to understand the role of glutathione S-transferase (GST) in carcinogenesis and its early diagnostic value for hepatocellular carcinoma, the carcinogenesis of rat hepatocarcinoma was induced by 2-acetamidofluorene (2-FAA) Dynamic changes of serum GST activity during the process. The results showed that after 2 weeks of 2-FAA ingestion, the serum GST activity increased significantly (P <0.05), and the activity of GST increased more than 4-fold in the 4th week compared with the normal control group (P < 0.01), and reached the peak value. Afterwards, the GST activity gradually decreased slowly and tended to be normal after 10 weeks. Studies have shown that GST is an early sign of carcinogenesis enzyme, serum GST activity detection of liver cancer early diagnosis has a certain value.