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目的:探讨在常规治疗基础上川芎嗪(商品名:川青)联合低分子肝素(商品名:速碧林)对原发性肾病综合征(PNS)的治疗效果。方法:将45例原发性肾病综合征患者随机分为2组,分别为常规治疗组(对照组)22例及川芎嗪联合低分子肝素治疗组(治疗组)23例,对照组给予激素、潘生丁、ACEI等药物治疗,治疗组在此基础上加用川芎嗪及低分子肝素。结果:治疗组与对照组治疗14天相比,其甘油三脂(TG)、胆固醇(TC)、血浆粘度、24小时尿蛋白定量、血肌酐均明显下降(P<0.05),血浆蛋白明显上升(P<0.05)。结论:在常规治疗基础上川芎嗪联合低分子肝素治疗PNS是一种有效的方法。
Objective: To investigate the therapeutic effect of ligustrazine (trade name: Chuanqing) combined with low molecular weight heparin (trade name: Supibulin) on primary nephrotic syndrome (PNS) based on routine treatment. Methods: Forty-five patients with primary nephrotic syndrome were randomly divided into two groups: 22 in the conventional treatment group (control group) and 23 in the ligustrazine plus low molecular weight heparin treatment group (treatment group). The control group was given hormone, Dipyridamole, ACEI and other drug treatment, the treatment group on the basis of the addition of ligustrazine and low molecular weight heparin. Results: Compared with the control group for 14 days, the triglyceride (TG), cholesterol (TC), plasma viscosity, 24-hour urine protein and serum creatinine were significantly decreased (P <0.05) (P <0.05). Conclusion: The combination of Ligustrazine and low molecular weight heparin in the treatment of PNS is an effective method based on routine treatment.