论文部分内容阅读
目的探讨葛脾煎剂对2型糖尿病(T2DM)大鼠肾病的保护作用及作用机制。方法高脂高糖饲料加小剂量链脲佐菌素建立T2DM大鼠模型,随机分为正常对照组(n=10)、糖尿病模型组(n=11)、葛脾煎剂组(n=11)和苯那普利组(n=11);8周处死大鼠,取血、尿、肾标本,检测血糖、肾功能、肾脏指数、TG、TC、MCP-1、TNF-α、IL-6及24hUAlb水平。结果与糖尿病组相比,葛脾煎剂组的MCP-1、TNF-α、IL-6和24hUAlb水平明显降低(P<0.05)。结论葛脾煎剂可能对糖尿病大鼠的肾病有保护作用。
Objective To investigate the protective effect and mechanism of Gepi decoction on nephropathy in type 2 diabetes mellitus (T2DM) rats. Methods T2DM rat models were established with high fat, high glucose diet and low dose of streptozotocin and randomly divided into normal control group (n=10), diabetic model group (n=11) and Gepi decoction group (n=11). ) and benazepril group (n=11); rats were sacrificed at 8 weeks and blood, urine, and kidney samples were taken for blood glucose, renal function, kidney index, TG, TC, MCP-1, TNF-α, IL- 6 and 24hUAlb levels. Results Compared with the diabetic group, the levels of MCP-1, TNF-α, IL-6 and 24hUAlb in the Gepi decoction group were significantly lower (P<0.05). Conclusion Gepi decoction may have protective effect on diabetic nephropathy in rats.