Synucleins蛋白家族成员中α ,β synuclein均在脑组织中首次发现 ,二者与神经系统疾病密切相关。二者与神经细胞的凋亡有一定的相关性 ,且 β synuclein能够影响α synuclein的功能。本文综述α ,β synuclein的生化特性、分布及其调控神经细胞凋亡的可能机制。 Α, β synuclein in Synucleins protein family members are all found in brain tissue for the first time, which are closely related to nervous system diseases. There is a certain correlation between the two and neuronal apoptosis, and β synuclein can affect the function of α synuclein. This review summarizes the biochemical characteristics and distribution of α, β synuclein and its possible mechanism of regulating neuronal apoptosis.