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目的:探讨微阵列比较基因组杂交胚胎植入前遗传学筛查(aCGH-PGS)技术对复发性流产(RM)患者辅助生殖临床结局的影响。方法:54例RM患者分为aCGH-PGS组(n=25)与非PGS组(n=29)。aCGH-PGS组胚胎行aCGH筛查,选择染色体整倍性胚胎植入,其临床结局与非PGS组相比较。结果:aCGH-PGS组中染色体整倍性胚胎占26.93%(42/156);平均移植胚胎1.3±0.8个,低于非PGS组2.6±0.6个(P<0.01);胚胎着床率(57.58%)与临床妊娠率(61.90%)高于非PGS组(27.03%,P<0.01;46.43%,P>0.05),早期流产率(7.69%)低于非PGS组(38.46%,P<0.01)。结论:经aCGH-PGS,植入1~2个染色体整倍性胚胎,可使RM患者获得更高的胚胎着床率及较低的早期流产率,是RM患者临床治疗的有效途径。
OBJECTIVE: To investigate the effect of aCGH-PGS (microarray hybridization comparative genomic hybridization embryo preimplantation genetic screening) on clinically assisted reproductive outcome in patients with recurrent spontaneous abortion (RM). Methods: 54 patients with RM were divided into aCGH-PGS group (n = 25) and non-PGS group (n = 29). The aCGH-PGS embryos were screened by aCGH and selected for echogenic embryo implantation. The clinical outcome was compared with that of non-PGS group. Results: The chromosome number of achondroplasia in aCGH-PGS group was 26.93% (42/156), the average number of embryos transferred was 1.3 ± 0.8, which was 2.6 ± 0.6 less than that in non-PGS group (P <0.01) (61.90%) was higher than non-PGS group (27.03%, P <0.01; 46.43%, P> 0.05), and the rate of early miscarriage was 7.69%, which was lower than that of non-PGS group (38.46%, P <0.01) ). CONCLUSIONS: Using aCGH-PGS to implant 1 or 2 chromosomes of euploid embryos, patients with RM can get higher embryo implantation rates and lower rates of early abortion, which is an effective approach for the clinical treatment of RM patients.