论文部分内容阅读
目的探讨腹腔镜联合孕三烯酮治疗子宫内膜异位症(EMs)对机体免疫功能及炎症状态的影响。方法选择43例有手术指征的EMs患者实施腹腔镜手术,术后第1次月经来潮的第1天服孕三烯酮2.5mg,2次/周,共6个月。术后6个月随访,取静脉血ELISA双抗体夹心法测定血清IL-2、IL-6、IL-10、和TNF-α。结果患者血清IL-2、IFN-γ较正常对照升高降低,术后恢复正常水平。IL-6、IL-10和TNF-α水平较正常对照升高,术后明显回落。结论腹腔镜手术联合治疗EMs患者对机体的免疫状态及炎症因子有一定影响。
Objective To investigate the effects of laparoscopy combined with gestrinone on endometriosis (EMs) on immune function and inflammatory status. Methods Forty-three patients with EMs who had surgical indications were enrolled in this study. Laparoscopic surgery was performed on the first day after menstruation. Gestheterone 2.5 mg twice daily for 6 months. After 6 months follow-up, serum IL-2, IL-6, IL-10 and TNF-α were measured by sandwich ELISA. Results Serum levels of IL-2 and IFN-γ in patients were higher than those in normal controls, and were normal after operation. The levels of IL-6, IL-10 and TNF-α were higher than those of normal control group, and obviously decreased after operation. Conclusions Laparoscopic surgery combined with EMs has some effect on immune status and inflammatory factors.