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目的:考察注射用炎琥宁与注射用头孢曲松钠在0.9%氯化钠注射液中的配伍稳定性。方法:采用高效液相色谱法,以Venusil XBP-C_(18)色谱柱,乙腈-0.02 mol·L~(-1)磷酸二氢钾-10%四丁基氢氧化铵(pH 5.0)(38:60.5:1.5)为流动相,252 nm为检测波长,测定注射用炎琥宁与注射用头孢曲松钠配伍后在室温下6 h内的含量变化,并观察和检测配伍液的外观及pH值变化。结果:配伍液pH值及含量无明显变化,但颜色随时间变化逐渐加深。结论:注射用炎琥宁与注射用头孢曲松钠在0.9%氯化钠注射液可配伍使用,但应在4 h内用完。
OBJECTIVE: To investigate the compatibility of injection of mesylate and ceftriaxone sodium for injection in 0.9% sodium chloride injection. Methods: High performance liquid chromatography (HPLC) was performed on a Venusil XBP-C 18 column with acetonitrile-0.02 mol·L -1 potassium dihydrogen phosphate-10% tetrabutylammonium hydroxide (pH 5.0) : 1.5) as the mobile phase, 252 nm as the detection wavelength, the determination of injection of mesylate and injection of ceftriaxone sodium compatibility within 6 h at room temperature within the content change, and observe and detect the appearance of the compatibility of the liquid and pH changes . Results: There was no obvious change in pH value and content of compatibility solution, but the color gradually deepened with time. Conclusion: Injection of mesylate and ceftriaxone sodium injection in 0.9% sodium chloride injection compatibility, but should be used within 4 h.