论文部分内容阅读
目的: 比较口服布洛芬悬液和消炎痛关闭早产儿动脉导管未闭 (PDA) 的治疗效果和安全性。方法: 30例胎龄 30~35周早产儿, 心脏彩超证实诊断为动脉导管未闭 (PDA), 随机分为布洛芬组 (n=15) 和消炎痛组 (n=15), 于生后 3d口服分 3次给药。布洛芬组首剂给予 10mg/kg, 于 24、48h后各给予 5mg/kg。消炎痛组 0 2mg(kg·次 ), 每间隔 12h1次。结果: 两组关闭率相似, 布洛芬组 12例导管关闭 (80% ), 消炎痛组 13例导管关闭 ( 87% ), 两组相比没有显著性差异 (P>0 .05)。布洛芬组 3例合并尿少, 消炎痛组 10例合并尿少, 两组相比有显著性差异 (P<0. 05), 消炎痛组 5例血肌酐增高, 6例血尿素氮增高, 布洛芬组无血肌酐增高, 1例血尿素氮增高, 两个项目均有显著性差异 (P<0. 05)。其他副作用无显著性差异,消炎痛组 2例大便潜血阳性, 1例血总胆红素轻度升高, 两组均无腹胀和坏死性小肠结肠炎发生。结论: 生后 3d口服布洛芬悬液治疗早产儿动脉导管未闭与口服消炎痛同样有效, 并能显著减少尿少和急性肾功能不全的发生。
Objective: To compare the efficacy and safety of oral ibuprofen suspension and indomethacin in the closure of patent ductus arteriosus (PDA) in preterm infants. Methods: 30 cases of preterm infants with gestational age of 30-35 weeks were diagnosed as patent ductus arteriosus (PDA) by randomized into ibuprofen group (n = 15) and indomethacin group (n = 15) After 3d oral administration 3 times. Ibuprofen group given the first dose of 10mg / kg, given after 24,48 h 5mg / kg. Indomethacin group 0 2mg (kg · times), every 12h1 times. Results: The closure rates were similar between the two groups, with 12 cases in the ibuprofen group closed (80%) and 13 cases in the indomethacin group closed (87%). There was no significant difference between the two groups (P> 0.05). In the ibuprofen group, there were 3 cases with less urine and 10 cases with indomethacin with less urine. There was significant difference between the two groups (P <0.05), serum creatinine increased in 5 cases and indomethacin increased in 6 cases , No serum creatinine increased in the ibuprofen group, and 1 blood urea nitrogen increased in both groups (P <0.05). No significant difference was found in other side effects. Fecal occult blood was positive in 2 patients in indomethacin group and slight increase in total bilirubin in 1 patient. No bloating and necrotizing enterocolitis occurred in both groups. CONCLUSIONS: 3d oral ibuprofen suspension for the treatment of patent ductus arteriosus in preterm infants is as effective as oral administration of indomethacin, and can significantly reduce the incidence of oliguria and acute renal insufficiency.