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目的观察胰岛素泵控制恶性肿瘤患者化疗期间高血糖的有效性和安全性。方法对2007年1月至2009年1月在肿瘤科住院的恶性肿瘤合并糖尿病患者76例随机分为治疗组和对照组,治疗组应用胰岛素泵控制血糖,对照组应用多次皮下胰岛素注射方法进行血糖控制;观察两组患者血糖控制所需时间及胰岛素用量、脱漏胰岛素注射次数、低血糖发生率和患者治疗满意度。结果治疗后两组空腹血糖及三餐后2小时平均毛细血管血糖均较治疗前明显下降(P<0.05),治疗后两组血糖结果比较虽治疗组较对照组数值低但组间无统计学差异(P>0.05)。两组患者平均血糖控制在10 mmol/L以下所用时间二者以及血糖控制于目标时胰岛素用量具有统计学差异(P<0.05)。结论采用胰岛素泵和多次皮下注射胰岛素2种治疗方案均可有效控制肿瘤患者化疗期间的高血糖状态,但胰岛素泵组控制时间更短、胰岛素用量更少,低血糖发生率更低,患者治疗依从性更高。
Objective To observe the effectiveness and safety of insulin pump in controlling hyperglycemia during chemotherapy in patients with malignant tumor. Methods From January 2007 to January 2009, 76 patients with malignant tumor and diabetes mellitus who were hospitalized in oncology department were randomly divided into treatment group and control group. In the treatment group, insulin pump was used to control the blood sugar. In the control group, multiple subcutaneous insulin injections were performed Blood glucose control; observed two groups of patients the time required for blood glucose control and insulin dosage, missed insulin injection times, the incidence of hypoglycemia and patient satisfaction with treatment. Results After treatment, the fasting blood glucose and mean capillary blood glucose in two hours after three meals were significantly lower than those before treatment (P <0.05). After treatment, although the treatment group was lower than the control group but there was no statistical difference between the two groups Difference (P> 0.05). There was a statistically significant difference between the two groups in terms of the mean duration of glycemic control below 10 mmol / L and the amount of insulin administered at the target glycemic control (P <0.05). Conclusion Both insulin pump and insulin pump can effectively control the hyperglycemia in cancer patients during chemotherapy, but the insulin pump group has shorter control time, less insulin dosage and lower incidence of hypoglycemia. More compliant.