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目的探讨不同高海拔地区急性脑梗死(acute cerebral infarction,ACI)与血浆同型半胱氨酸(Homocysteine,Hcy)水平的关系。方法采用发光免疫法测定高海拔地区ACI患者40例,中度海拔地区ACI患者48例及70例不同海拔健康对照组血浆Hcy、叶酸(FA)和维生素B12(VitB12)浓度。结果不同海拔地区ACI组患者血浆Hcy水平明显升高,FA水平明显低于各对照组(P<0.01)。与中度海拔ACI组相比,高海拔ACI组Hcy水平显著增高,FA的含量显著降低。健康对照组随着海拔增高Hcy的含量增高而FA的含量降低。VitB12在4组间变化不大。ACI组Hcy与FA间呈负相关(r=-0.034,P<0.05)。与VitB12相关不显著。结论高Hcy血症与高原地区急性脑梗死有密切关系。
Objective To investigate the relationship between acute cerebral infarction (ACI) and plasma homocysteine (Hcy) in different altitude regions. Methods The levels of plasma Hcy, folic acid (FA) and vitamin B12 (VitB12) in 40 patients with ACI in high altitude area, 48 patients with ACI in mid-altitude area and 70 healthy people at different altitudes were measured by luminescence immunoassay. Results The plasma Hcy levels in ACI group were significantly higher at different altitudes, and the levels of FA were significantly lower than those in control group (P <0.01). Compared with the moderate altitude ACI group, the Hcy level in ACI group increased significantly and the FA content decreased significantly. In the healthy control group, the content of Hcy increased while the content of FA decreased as the altitude increased. VitB12 changed little among the 4 groups. There was a negative correlation between Hcy and FA in ACI group (r = -0.034, P <0.05). Not relevant to VitB12. Conclusion Hyperhomocysteinemia is closely related to acute cerebral infarction in the plateau area.