论文部分内容阅读
近年来大多数治疗眼内炎的方案均包括向玻璃体注射氨基糖甙类抗生素,并发现氨基糖甙类抗生素对视网膜的毒性是一个值得注意的问题.作者收集了玻璃体内注射硫酸阿米卡星0.2～0.4mg或硫酸庆大霉素0.1～0.2mg以防治眼内炎的13例患者的病史,对患者的体征和方程等关键性细节进行调查和总结.结果表明,这些病例提示阿米卡星和低剂量庆大霉素,与庆大霉素一样,也能导致黄斑梗塞.导致所有病例病变的药物剂量还不能确定,但医院药剂师按照打印的规则配制药物,这种规则有助于避免发生稀释误差.许多病例与先前报道的使用氨基糖甙抗生素所致毒性不同,这些病例的黄斑分布十分散在.大多数患者视力损害严重,但有2例的大部分无灌注区邻近有黄斑,而且一些中央四周围毛细管稀疏,视力恢复到20/50.
In recent years, most of the treatment of endophthalmitis programs include the injection of aminoglycoside antibiotics to the vitreous and found that aminoglycoside antibiotics on the toxicity of the retina is a noteworthy issue. The authors collected intravitreal injection of amikacin sulfate 0.2 ~ 0.4mg or gentamicin 0.1 ~ 0.2mg to prevent endophthalmitis in 13 patients history, the patient’s signs and equations and other key details of the investigation and summary of the results show that these cases prompted Amika Star and low-dose gentamicin, like gentamicin, can also cause macular infarction.The dosage of the drug that causes the disease in all the cases can not be determined, but the hospital pharmacist formulates the medicine according to the printing rules, which helps To avoid dilution error.In many cases and previously reported the use of aminoglycoside antibiotics caused by the toxicity of the macular distribution in these cases is very scattered in most patients with severe visual impairment, but most of the non-perfusion area in 2 cases near the macular, And some central around the sparse capillary, visual acuity recovered to 20/50.