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近年来由于抗生素的滥用,药物的剂量过大以及不适当的配伍,引起肾脏的损害愈来愈受到人们的重视。但同时引起肝肾两个器官的损害病例甚少。现报告一例因服用磺胺类、解热镇痛类引起的肝肾损害。1.病例介绍 患儿,男,5岁,主因尿黄、肝功异常收传染科。入院后发现患儿为血尿,经儿科会诊,考虑中毒性肝炎、急性间质性肾炎,于97年7月1日转入儿科。2天前患儿因上感服增效联磺片,安乃近各2＃/次,2次/日,共4＃,之后出现血尿,为无痛性全程血尿,无膀胱刺激征,无结核接触史。体检:T37.5℃,一般情况可,肝肋下约4cm,剑突下约2cm,质韧,边钝,有触痛;脾肋下约2cm,质软,边钝,有触痛。肝区、脾区、双肾区叩击
In recent years, due to the abuse of antibiotics, excessive doses of drugs and improper compatibility, causing kidney damage more and more people’s attention. But at the same time, few cases of liver and kidney damage caused by two organs. Now report a case due to taking sulfonamides, anti-inflammatory analgesic liver and kidney damage caused. 1. Case description Children, male, 5 years old, mainly due to urinary yellow, liver abnormalities received Department of Infectious Diseases. He was admitted to hospital for hematuria, the pediatric consultation, consider toxic hepatitis, acute interstitial nephritis, on July 1, 1997 into pediatrics. Two days ago, the children were convicted because of the synergistic effect of sulfasulfan and metamizole 2 # / times, 2 times / day, a total of 4 #, followed by hematuria, painless hematuria, no bladder irritation, no tuberculosis Contact history. Physical examination: T37.5 ℃, the general situation can be, about 4cm under the liver ribs, xiphoid about 2cm, quality tough, blunt, tenderness; spleen rib about 2cm, soft, blunt, tenderness. Liver, spleen, kidney area percussion