众所周知,磺胺对于细菌并不是起直接杀菌的作用,而只是抑制它的生长和繁殖。根据伍德-费尔德氏(Woods-Fildes)理论,磺胺对细菌的作用机制是:对氨苯甲酸(PABA)是细菌新陈代谢的必需物。细菌经过酶的作用才能利用此物合成核酸或蛋白质。磺胺的化学结构与PABA相似,当磺胺达到一定浓度时,就可以与细菌体内利用PABA的酶相结合,使细菌对PABA的利用受到影响,从而抑制其生长繁殖。 It is well-known that sulfanilamide does not act as a direct bactericidal agent against bacteria, but rather inhibits its growth and reproduction. According to Woods-Fildes theory, the mechanism of action of sulfa on bacteria is that p-aminobenzoic acid (PABA) is an essential bacterial metabolism. Bacteria through the enzyme to use this material to synthesize nucleic acids or proteins. The chemical structure of sulfanilamide is similar to that of PABA. When sulfonamide reaches a certain concentration, it can combine with PABA enzyme in bacteria so as to inhibit the utilization of PABA by bacteria and thus inhibit its growth and reproduction.