目的:胰岛素抵抗是高血压和其它心血管疾病的重要危险因素之一,而内皮细胞功能异常是胰岛素抵抗的早期表现。内皮细胞功能异常与高血压发病机制的关系众说纷纭。既往研究多集中于内皮细胞功能紊乱与动脉粥样硬化的关系,但关于胰岛素对血压的作用以及在胰岛素抵抗状态下内皮细胞功能变化与高血压的关系研究甚少,现综述如下。 PURPOSE: Insulin resistance is one of the important risk factors of hypertension and other cardiovascular diseases. However, endothelial dysfunction is an early manifestation of insulin resistance. The relationship between endothelial dysfunction and the pathogenesis of hypertension varies. Previous studies mostly focused on the relationship between endothelial dysfunction and atherosclerosis. However, little is known about the effect of insulin on blood pressure and the relationship between endothelial function and hypertension in insulin resistance.