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目的了解妊娠期母血表皮生长因子（ＥＧＦ）和绒毛膜促性腺激素（ＨＣＧ）的浓度变化及其生理学意义。方法采用放射免疫法测定１８２例不同孕龄的孕妇血清ＥＧＦ和ＨＣＧ含量，２０例健康非孕妇女作为对照组。结果与非孕妇女比较，妊娠妇女血ＥＧＦ含量明显增高（Ｐ＜０．０１）；早孕时ＥＧＦ含量几乎呈直线上升，至孕２４～２７周达高峰，以后迅速下降。早期及晚期妊娠时，ＥＧＦ含量与ＨＣＧ含量呈良好正相关（Ｐ＜０．０１，Ｐ＜０．０５），而中期妊娠时，两者无明显相关性；足月妊娠的新生儿体重较重者，母血ＥＧＦ浓度较高，但无统计学差异。结论妊娠期ＥＧＦ含量变化对ＨＣＧ分泌调节可能有一定关系，并对胎盘功能和胎儿发育产生影响
Objective To understand the changes of maternal serum epidermal growth factor (EGF) and human chorionic gonadotropin (HCG) during pregnancy and their physiological significance. Methods The serum levels of EGF and HCG in 182 pregnant women with different gestational ages were determined by radioimmunoassay. Twenty healthy non-pregnant women served as the control group. Results Compared with non-pregnant women, EGF levels in pregnant women were significantly increased (P <0.01). The content of EGF increased almost linearly in early pregnancy and peaked at 24-27 weeks, then decreased rapidly. There was a positive correlation between EGF content and HCG content in early pregnancy and late pregnancy (P <0.01, P <0.05), but there was no significant correlation between EGF content and gestational age Who, maternal serum EGF concentration higher, but no significant difference. Conclusion The changes of EGF content in pregnancy may have a certain relationship with the regulation of HCG secretion, and have an impact on the placental function and fetal development