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目的观察血浆内源性一氧化碳(CO)水平与阻塞性睡眠呼吸暂停综合征(OSAS)及高血压之间的关系。方法收集自述或家属述有夜间打鼾者115例,进行多导睡眠呼吸监测及24h动态血压检测,根据测定的结果分为对照组、单纯OSAS、单纯高血压组、OSAS合并高血压组。测定各组血浆内源性CO,比较各组血浆CO水平的差异,并分析血浆CO水平的影响因素。结果单纯OSAS组和OSAS合并高血压组血浆CO高于单纯高血压组和对照组,差异有统计学意义(P<0.05);多元线性回归分析示,睡眠呼吸紊乱指数与CO水平正相关,(β=0.012,P=0.005)。结论 OSAS人群血浆内源性CO水平高于非OSAS人群,血浆内源性CO水平在高血压和非高血压人群间没有差异;血浆内源性CO水平与OSAS夜间低氧正相关,而与血压无关。
Objective To observe the relationship between plasma endogenous carbon monoxide (CO) level and obstructive sleep apnea syndrome (OSAS) and hypertension. Methods One hundred and fifteen cases of narcolepsy or night snore were collected for polysomnography and 24h ambulatory blood pressure testing. According to the results of the study, the patients were divided into control group, OSAS group, simple hypertension group and OSAS combined hypertension group. Plasma endogenous CO was measured in each group, and plasma CO levels were compared between groups, and the influencing factors of plasma CO level were analyzed. Results The plasma levels of CO in OSAS group and OSAS group were significantly higher than those in hypertension group and control group (P <0.05). Multivariate linear regression analysis showed that sleep disordered breathing index was positively correlated with CO level β = 0.012, P = 0.005). Conclusions Plasma endogenous levels of CO in OSAS population are higher than those in non-OSAS population. There is no difference in plasma endogenous CO levels between hypertensive and non-hypertensive subjects. Plasma endogenous CO levels are positively correlated with nighttime hypoxia in OSAS, Nothing to do