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Synthesis and characterization of the ligand, [2-tetradecyl-3,6,9-tris(carboxymethyl)-3,6,9-triazaundecan-1,11-dioic acid, H5L] and its Gd(Ⅲ) chelate are described. Protonation constants for H5L (lgKiH = 10.80, 8.40, 4.30, 2.80, 2.15) and the stability constant for GdL2- (lgK■ = 22.75) were determined by potentiometric titration and are similar with the related values of DTPA and Gd-DTPA respectively. The results obtained show that the basicity of the ligand and the stability constant of its Gd(Ⅲ) chelate are not obviously altered after introduction of a linear chain tetradecyl group at the terminal acetic acid residue of DTPA.
Synthesis and characterization of the ligand, [2-tetradecyl-3,6,9-tris (carboxymethyl) -3,6,9-triazaundecan-1,11-dioic acid, H5L] and its Gd (III) chelate are described. Protonation constants for H5L (lgKiH = 10.80, 8.40, 4.30, 2.80, 2.15) and the stability constant for GdL2- (lgK ■ = 22.75) were determined by potentiometric titration and are similar to the related values of DTPA and Gd-DTPA respectively. The results obtained show that the basicity of the ligand and the stability constant of its Gd (III) chelate are not visible altered after introduction of a linear chain tetradecyl group at the terminal acetic acid residue of DTPA.