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目的明确胍丁胺抗抑郁作用与咪唑啉受体的关系。方法与结果连续给予CD-1小鼠胍丁胺(10mg/kg,qd,ig)3d,最后一次给药后1h进行强迫游泳或悬尾实验,与盐水对照组相比,胍丁胺可以显著缩短小鼠强迫游泳及悬尾不动时间(P<0.05);连续给予依法克生(0.1mg/kg,qd,ip)或咪唑克生(1mg/kg,qd,ip)3d,最后一次给药后30min进行实验,对小鼠强迫游泳及悬尾不动时间均无显著影响(P>0.05);但伴随胍丁胺连续给予(15min前),依法克生(0.1mg/kg)及咪唑克生(1mg/kg)均能逆转胍丁胺缩短小鼠强迫游泳及悬尾不动时间的作用(P<0.05)。结论胍丁胺对小鼠具有抗抑郁样作用,且与激活咪唑啉受体相关。
Objective To investigate the relationship between agmatine antidepressant and imidazoline receptor. Methods and Results Agmatine (10mg / kg, qd, ig) was administered to CD-1 mice continuously for 3 days. Forced swimming or tail suspension test was performed at 1 hour after the last administration. Compared with saline control group, agmatine was significantly (P <0.05). The mice were infused with either imazethapyr (0.1 mg / kg, qd, ip) or mizolac (1 mg / kg, qd, ip) The test was carried out 30 min after drug administration, and had no significant effect on the forced swimming and immobility time in mice (P> 0.05). However, with continuous administration of agmatine (before 15 min) Ketan (1 mg / kg) could reverse the effect of agmatine on forced swimming and tail-suspending time in mice (P <0.05). Conclusion Agmatine has antidepressant-like activity in mice and is associated with activation of imidazolinium receptors.