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目的：探讨高原系统性红斑狼疮（ＳＬＥ）心脏损害的各期变化与演变过程。方法：３０例高原ＳＬＥ全病程资料，按病程分为５个年限梯度，分析Ｍ型、二维超声、多普勒测定的各心脏结构与功能参数，判定其统计学意义。结果：①高原ＳＬＥ心脏损害始于右室，然后依次累及右房、左室、左房；②其损害类型为先扩大，后肥厚；③心包积液发生于病情活动期与危重期；④危重期心脏结构与功能重叠受累。结论：高原ＳＬＥ心脏损害的基本演变过程为先右后左，先室后房，早期扩大，继而肥厚；无论病程长短，危重期多出现极严重的心脏影像学异常。
Objective: To investigate the changes and evolution of heart damage in patients with plateau systemic lupus erythematosus (SLE). Methods: The data of 30 cases of SLE in the plateau were divided into 5 years according to the duration of disease. The cardiac structure and function parameters of M type, 2-dimensional ultrasound and Doppler were analyzed to determine their statistical significance. Results: ① The SLE heart damage in the plateau began in the right ventricle, and then followed by the right atrium, left ventricle and left atrium; ② its type of injury was first enlarged and then hypertrophy; ③ pericardial effusion occurred in active stage and critical stage; ④ critically ill Period heart structure and function overlap. CONCLUSION: The basic evolution of SLE heart damage in the plateau is that the right and left first, the anterior chamber anterior chamber enlarge early and then hypertrophy; and the most serious cardiac imaging abnormalities occur at critical stage regardless of course of disease.