In the present study we explored the different patterns of volumetric atrophy in hippocampal subregions of patients with left and right mesial temporal lobe epilepsy with hippocampal sclerosis (TLE-HS).Meanwhile,the memory impairment patterns in Chinese-speaking TLE-HS patients and potential influencing factors were also determined.TLE-HS patients (21 left and 17 right) and 21 healthy controls were recruited to complete T2-weighted imaging and verbal/nonverbal memory assessment.The results showed that both left and right TLE-HS patients had overall reduced hippocampal subregion volumes on the sclerotic side,and cornu ammonis sectors (CA1) exhibited maximum atrophy.The verbal memory of left TLE-HS patients was significantly impaired (P ＜ 0.001) and was not associated with the volumes of the left hippocampal subregions.Verbal or nonverbal memory impairment was not found in the patients with right TLE-HS.These results suggested that the atrophy of hippocampal subregion volumes cannot account for the verbal memory impairment,which might be related to the functional network.