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交感神经递质去甲肾上腺素(NE),神经肽Y(NPY)与高血压、动脉粥样硬化及脑卒中等疾病关系密切.实验用健康雄性SD大鼠96只,体重80—110g/只,随机分四组:1.对照组(24只):行假手术、普通饮食;2.高血压组(24只):用双肾双夹法复制易卒中型肾血管性高血压大鼠(RHRSP)模型、普通饮食,3.高脂组(24只):行假手术、高脂饮食;4.高血压+高脂组(24只):复制RHRSP模型、高脂饮食.各组分别手术后1周、4周、12周处死,取双侧大脑中动脉、基底动脉、ABC免疫组化染色,定量分析血管壁NE、NPY阳性神经纤维密集变化,结果发现:1.NE能神经纤维:对照组各期无明显变化;高血压组晚期显著减少(P<0.01);高脂组早
Sympathetic neurotransmitter norepinephrine (NE), neuropeptide Y (NPY) and hypertension, atherosclerosis and stroke and other diseases are closely related to the experimental use of 96 healthy male SD rats, weighing 80-110g / only Were randomly divided into four groups: 1. Control group (24 rats): sham operation, general diet; 2.Hypertension group (24 rats): Renal stroke patients with Renovascular Hypertension RHRSP model, normal diet, high fat diet group (24 rats): sham operation and high fat diet; 4 hypertension and hyperlipidemia group (24 rabbits): replicating RHRSP model and high fat diet, After 1 week, 4 weeks and 12 weeks after operation, bilateral middle cerebral artery, basilar artery and ABC immunohistochemical staining were performed to quantitatively analyze the dense changes of NE and NPY positive nerve fibers in vascular wall. The results showed that: 1. NE nerve fibers: The control group had no significant changes in each phase; the late hypertension group significantly decreased (P <0.01); the hyperlipidemia group had earlier