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目的探讨血胱抑素C(cys-C)在窒息新生儿肾损害的早期诊断意义。方法选择符合诊断标准的窒息新生儿240例,按出生时Apgar评分分为轻度窒息144例,重度窒息96例,同期选择60例健康足月新生儿作为对照组。窒息新生儿在入院后第1天,对照组新生儿在出生后1～3 d抽取外周静脉血3 ml,分别检测血cys-C,尿素氮(Bun)和肌酐(Scr),并进行统计学分析。结果①轻度窒息组和重度窒息组血清cys-C均较对照组显著升高(P<0.01),重度窒息组血清cys-C较轻度窒息组显著升高(P<0.01);②轻度窒息组血清cys-C的异常率与Bun和Scr的异常率差异有统计学意义(均P<0.05),重度窒息组血清cys-C的异常率与Bun、Scr的异常率差异有统计学意义(均P<0.01)。结论血清cys-C可作为窒息新生儿肾功能损伤的早期诊断指标,在重度窒息组其敏感性高于血Bun、Scr。
Objective To investigate the early diagnosis of renal damage in neonatal asphyxia with cys-C. Methods A total of 240 asphyxiated neonates with diagnostic criteria were selected and divided into mild asphyxia (n = 144) and severe asphyxia (n = 96) according to Apgar score at birth. Sixty healthy full-term newborns were selected as control group. On the first day after admission, newborns in the control group were drawn 3 ml of peripheral venous blood from 1 to 3 days after birth to detect the levels of cys-C, Bun and creatinine (Scr) analysis. Results ① The levels of serum cys-C in mild asphyxia group and severe asphyxia group were significantly higher than those in control group (P <0.01), while the levels of serum cys-C in severe asphyxia group were significantly higher than those in mild asphyxia group (P <0.01) There were significant differences in the abnormal rate of serum cys-C and Bun and Scr between degrees of asphyxia group (all P <0.05), abnormal rates of serum cys-C and Bun, Scr in severe asphyxia group were statistically significant Significance (all P <0.01). Conclusion Serum cys-C can be used as an early diagnosis indicator of neonatal renal dysfunction in asphyxia, and its sensitivity in severe asphyxia group is higher than that of blood and Scr.