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目的探讨乳腺癌与c-erbB-2,PS2的表达及预后的相关性。方法应用免疫组织化学S-P法,检测100例乳腺癌c-erbB-2,PS2表达状况。结果c-erbB-2,PS2阳性表达率分别为52%,44%。c-erbB-2阳性表达率与分化程度、淋巴结转移之间呈正相关性,PS2的阳性率与5年生存期呈正相关。结论c-erbB-2与乳腺癌的预后关系密切,PS2蛋白的表达对患者的内分泌治疗有一定指导意义。
Objective To investigate the correlation between breast cancer and the expression and prognosis of c-erbB-2 and PS2. Methods The expression of c-erbB-2 and PS2 in 100 cases of breast cancer was detected by immunohistochemical S-P method. Results The positive rates of c-erbB-2 and PS2 were 52% and 44% respectively. The positive rate of c-erbB-2 was positively correlated with the degree of differentiation and lymph node metastasis. The positive rate of PS2 was positively correlated with 5-year survival rate. Conclusion The prognosis of c-erbB-2 is closely related to the prognosis of breast cancer. The expression of PS2 protein may play a guiding role in the endocrine therapy of patients.