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目的 :探讨车祸应激对心理、生化免疫的影响。方法 :对住我院骨科治疗的车祸致伤患者 12 0例 (研究组 )及非车祸致伤患者 67例 (对照组 )进行了SCL -90、EPQ的测评。将研究组按EPQ评分中N分<43 3分为情绪稳定组 ,N分 >5 6 7分为情绪不稳定组。同时采用放射免疫法测定研究组、对照组的血清细胞因子白细胞介素 1β (IL -1β)、IL -2、IL -8及皮质醇 (F)水平。 结果 :与对照组比较 ,SCL -90总分及 5个因子分均增高 (P <0 0 5～ 0 0 1) ,且各因子分与EPQ问卷中N分、P分成正相关 ,与L分、E分成负相关。研究组的IL -1β、IL -2、IL -8分别为 0 2 0± 0 6ng/ml、 2 5 0 9± 9 5 1ng/ml、0 10± 0 0 7ng/ml、较对照组均降低 (P <0 0 5～ 0 0 1)。F水平为 2 4 0 1± 6 2 9ng/ml ,较对照组增高 (P <0 0 1)。与情绪不稳定组比较 ,情绪稳定组白细胞介素水平增高 (P <0 0 5 )。结论 :车祸致伤患者较非车祸致伤患者心理健康水平下降 ,免疫系统激活程度相对偏低。心理问题的发生与个性特征有一定的关系 ,健康的人格特征可能增强个体抗应激能力
Objective: To investigate the impact of car accident stress on psychological and biochemical immunity. Methods: SCL-90 and EPQ were evaluated in 120 patients (study group) and 67 non-car accident-injured patients (control group) who were injured in car accident in our hospital. According to the EPQ score, the research group divided N score <43 3 into emotion stability group, and N score> 567 into emotional instability group. At the same time, the levels of serum cytokines IL-1β, IL-2, IL-8 and cortisol (F) in the study group and the control group were determined by radioimmunoassay. Results: Compared with the control group, the scores of SCL-90 and five factors increased (P <0.05-0.01), and all the factors were positively correlated with N and P in the EPQ questionnaire, , E is divided into negative correlation. The levels of IL-1β, IL-2 and IL-8 in the study group were respectively 0 2 0 ± 0 6ng / ml, 259 ± 9 5 1ng / ml and 0 10 ± 0 0 7ng / ml, which were lower than those in the control group (P <0 0 5 ~ 0 0 1). F level was 240 ± 6 2 9ng / ml, which was higher than that of the control group (P <0.01). Compared with the emotionally unstable group, the level of interleukin in emotionally stable group increased (P <0.05). Conclusion: The car accident injured patients than non-car accident hurt the mental health level decreased, the activation of the immune system is relatively low. The occurrence of psychological problems and personality traits have a certain relationship, healthy personality traits may enhance the individual anti-stress ability