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目的:探讨运脾温阳颗粒对脾虚动物血清中NO、胃泌素和白介素-10浓度的影响。方法:分别用利血平皮下注射大鼠和大黄灌胃小鼠造成脾虚模型,然后用运脾温阳颗粒治疗后测定血清中NO,胃泌素浓度和白介素-10浓度。结果:模型组动物血清NO、胃泌素和白介素-10浓度降低,运脾温阳颗粒治疗组血清NO、胃泌素和白介素-10浓度升高,与模型组比较有显著性差异。结论:运脾温阳颗粒能够升高脾虚动物血清NO、胃泌素和白介素-10浓度,改善脾虚症状。
Objective: To investigate the effect of Yunpi Wenyang Granule on the concentration of NO, gastrin and interleukin-10 in serum of spleen deficiency animal. METHODS: Spleen deficiency model was induced by subcutaneous injection of reserpine into rats and rhubarb mice, and then NO, gastrin concentrations and interleukin-10 concentrations in serum were measured after treatment with Yunpi Wenyang Granules. Results: The serum levels of NO, gastrin, and interleukin-10 were decreased in the model group, and the concentrations of NO, gastrin, and interleukin-10 were increased in the Yunpi Wenyang Granule treatment group, which was significantly different from the model group. Conclusion: Yunpi Wenyang Granules can increase the concentration of NO, gastrin and interleukin-10 in serum of spleen deficiency animal and improve the symptoms of spleen deficiency.