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本文作者研究了自制重组γ－干扰素对裸鼠人肝癌移植瘤的抑瘤效应。结果提示重组γ－干扰素确有一定的抑瘤作用。给药后，带瘤小鼠的血清ＡＦＰ含量明显降低，与对照动物比较，差异非常显著（Ｐ＜０．０１），且与其给药剂量呈正相关系（Ｐ〈０．０５）。腹腔给药与肌肉注射的抑瘤作用有别，后者荷瘤裸鼠的肿瘤体积的增长速度远低于对照动物（Ｐ＜０．０５），作者推测可能与药物在体内滞留作用时间相对较长有关。
The authors studied the anti-tumor effect of self-made recombinant interferon-gamma on human hepatoma xenografts in nude mice. The results suggest that recombinant γ-interferon does have a certain anti-tumor effect. After administration, the serum AFP level in tumor-bearing mice was significantly lower than that in control animals (P <0.01), and positively correlated with the dosage of AFP (P <0.05). Intraperitoneal administration and intramuscular injection of anti-tumor effect are different, the latter tumor-bearing nude mice tumor growth rate was significantly lower than the control animals (P <0.05), the authors speculated that drug retention time in vivo relatively Long related.