报道了在温和条件下通过镍和联吡啶催化的还原偶联反应,由C(l)-卤代糖苷和缺电子的芳基溴化物制备芳香糖苷类化合物的方法.运用该种方法可以由中等或高的α-选择性得到芳香碳糖苷类产物.包括富电子的芳香碘化物在内的多种卤代芳烃底物适用于该反应,产率在40％～95％之间.该方法可以放大到克级规模,并在此条件下将镍催化剂的用量减少到2 mol％.“,”The preparation of C-aryl glycosides via mild Ni/bipyridine-catalyzed reductive arylation of C(l)-glycosyl halides with electron-deficient aryl bromides was developed.Moderate to high α-selectivities were achieved for C-glycosides.A broad range of aryl halides including electron-rich aryl iodides were employed to yield C-aryl glycosides in 40％～5％yields.This method can be scaled up on a gram scale by lowering the loading of nickel catalyst to 2 mol％.