患者男,25岁。躯干及四肢皮肤出现丘疹、脓疱、坏死及结痂1年余。结核菌素试验强阳性。皮损组织病理示:真皮浅层及中层灶性胶原纤维变性坏死,周围散在及灶状淋巴细胞、组织细胞浸润,并可见纤维母细胞增生及少量类上皮细胞、多核巨细胞聚集。诊断:丘疹坏死性结核疹。 Male patient, 25 years old. Trunk and limb skin pimples, pustules, necrosis and crusting more than 1 year. Tuberculin test is strongly positive. Histopathological examination showed that the superficial and middle layers of collagenous fibers in the dermis were degenerated and necrotic, surrounded by scattered and infiltrating lymphocytes and tissue cells. The proliferation of fibroblasts and a few epithelial cells and multinucleated giant cells gathered. Diagnosis: papular necrotizing tuberculosis.