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目的观察法舒地尔注射液治疗蛛网膜下腔出血后脑血管痉挛的疗效和安全性。方法选择在本院住院的蛛网膜下腔出血患者67例,随机分为两组,观察组34例,对照组33例,两组患者均在常规治疗的基础上,观察组给予法舒地尔注射液治疗,对照组给予尼莫地平注射液治疗,疗程15d,疗程结束后比较两组患者的临床表现、病情变化、意识的改善、血压及Hunt & Hess分级等指标。结果两组患者在疗程结束后,总有效率比较差异有统计学意义,观察组的疗效明显优于对照组(P<0.05),观察组的不良反应发生率低于对照组。结论治疗蛛网膜下腔出血后脑血管痉挛,法舒地尔注射液是一种较尼莫地平同样安全而疗效更好的药物。
Objective To observe the efficacy and safety of fasudil injection in the treatment of cerebral vasospasm after subarachnoid hemorrhage. Methods Sixty-seven patients with subarachnoid hemorrhage hospitalized in our hospital were randomly divided into two groups: 34 cases in observation group and 33 cases in control group. Both groups were treated on the basis of routine treatment. The observation group was fasudil The control group was given nimodipine injection for 15 days. After the course of treatment, the clinical manifestations, changes in condition, improvement of consciousness, blood pressure and Hunt & Hess grading were compared. Results After two courses of treatment, the total effective rate was significantly different. The curative effect of the observation group was better than that of the control group (P <0.05). The incidence of adverse reactions in the observation group was lower than that of the control group. Conclusions Treatment of cerebral vasospasm following subarachnoid hemorrhage, fasudil injection, is a more safe and efficacious drug than nimodipine.