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目的通过测定血清β2-微球蛋白(β2-MG)与胱抑素C(CYC)水平,探讨二者联合检测对早期糖尿病肾病(DN)诊断的临床价值。方法选取我院诊治的糖尿肾病患者(DN)50例,同时从我院体检中心选取近期体检的健康人员60例作对照组,分别检测血清β2-MG与CYC。结果与健康对照组相比,DN组β2-MG与CYC两项指标均显著升高,差异具有统计学意义(P<0.05)。结论β2-MG与CYC二者联合检测对于早期DN的诊断和防治有重要的指导意义。
Objective To investigate the clinical value of the combined detection of β2-microglobulin (β2-MG) and cystatin C (CYC) in the diagnosis of early diabetic nephropathy (DN). Methods Fifty patients with diabetic nephropathy (DN) were selected for diagnosis and treatment in our hospital. Sixty healthy subjects from the physical examination center of our hospital were selected as the control group. Serum β2-MG and CYC were detected respectively. Results Compared with the healthy control group, both the β2-MG and CYC indexes in DN group were significantly increased, the difference was statistically significant (P <0.05). Conclusion The combined detection of β2-MG and CYC has important guiding significance for the diagnosis and prevention of early DN.