论文部分内容阅读
目的通过对肺炎衣原体抗体水平、血脂及C反应蛋白(CRP)的观察,探讨肺炎衣原体感染与老年急性脑梗死的相关性。方法选取2013年3月至2014年3月住院的老年急性脑梗死患者65例作为研究组,以同时期健康体检者65人作为对照组,检测其血清肺炎衣原体特异性抗体Ig A、Ig M、Ig G及血脂(TC、LDL、TG、HDL)和CRP。结果研究组Ig A、Ig G抗体阳性率和慢性感染率均显著高于对照组,而Ig M抗体阳性率和急性感染率两组间无显著性差异(P>0.05);研究组TC、LDL、TG及CRP水平均显著高于对照组,HDL水平则显著低于对照组(P<0.01);研究组感染病例血脂及CPR水平与未感染病例差异性显著(P均<0.05),具有统计学意义;Ig A、Ig G抗体阳性为老年急性脑梗死独立危险因素,Ig M抗体阳性与之无相关性。结论肺炎衣原体慢性感染与老年急性脑梗死相关,肺炎衣原体可能通过血脂代谢异常及炎症反应参与急性脑梗死的病变过程。
Objective To investigate the relationship between Chlamydia pneumoniae infection and acute cerebral infarction in Chlamydia pneumoniae by observing the antibody levels of Chlamydia pneumoniae, blood lipids and C-reactive protein (CRP). Methods Sixty-five elderly patients with acute cerebral infarction who were hospitalized from March 2013 to March 2014 were selected as the study group. Sixty-five healthy individuals were enrolled as the control group. Serum anti-Chlamydia pneumoniae specific IgA, IgM, Ig G and blood lipids (TC, LDL, TG, HDL) and CRP. Results The Ig A and Ig G positive rate and the chronic infection rate in the study group were significantly higher than those in the control group, while there was no significant difference between the IgM antibody positive rate and the acute infection rate (P> 0.05) , TG and CRP levels were significantly higher than the control group, HDL levels were significantly lower than the control group (P <0.01); the study group of patients with blood lipids and CPR levels and non-infected cases were significantly different (P all <0.05) Significance; Ig A, Ig G antibody positive independent risk factors for senile acute cerebral infarction, Ig M antibody positive with no correlation. Conclusion Chlamydia pneumoniae is associated with acute cerebral infarction. Chlamydia pneumoniae may be involved in the pathogenesis of acute cerebral infarction through dyslipidemia and inflammation.