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成熟神经元不可再生,完全缺血5 min即可导致神经元不可逆性死亡。电刺激小脑顶核具有脑保护作用,能提高脑缺血大鼠对缺血、缺氧的耐受性,但其具体机制不明。主要从抑制炎性反应、降低缺血半暗带的电兴奋性、抑制神经元凋亡、促进结构重建、功能恢复、促进内源性神经干细胞生长等方面就电刺激小脑顶核的内源性神经保护机制进行阐述,尤其关注到它促进内源性神经干细胞生长对缺血性脑血管病的意义。
Mature neurons are not regenerated, 5 min of complete ischemia can lead to irreversible neuronal death. Electrical stimulation of the cerebellar fastigial nucleus has a protective effect on the brain, can improve the ischemic and hypoxic tolerance of cerebral ischemia rats, but its specific mechanism is unknown. Mainly from the inhibition of inflammatory response, reduce the electrical excitability of ischemic penumbra, inhibition of neuronal apoptosis, promote structural remodeling, functional recovery, and promote the growth of endogenous neural stem cells and other aspects of the electrical stimulation of cerebellar apical nuclear endogenous Neuroprotection mechanism elaborated, with particular attention to its promotion of endogenous neural stem cell growth on ischemic cerebrovascular disease significance.