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在15只麻醉开胸犬中,用在体器官恒流灌注法研究了骨骼肌、皮肤、肾和心脏的血管在5-HT诱发的主动脉区化学感受性升血压反射中的反应,同时还观察了5-HT对这些器官血管的直接效应。左心房注入5-HT(200μg)后,在动血压急剧上升的向时,股薄肌、皮肤(后爪)和肾脏的灌流压明显增加,其增分别为43±8、47±5和56±27mmHg(P<0.01),而冠脉灌流压无明显改变。用阿托品和/或心得安阻断骨骼肌、皮肤和心脏灌流区域的m和β-受体后,上述效应无
In 15 anesthetized thoracodorsal dogs, responses to 5-HT-induced aortic chemoreflex in skeletal muscle, skin, kidneys and heart were studied by constant flow perfusion in vivo and in vivo The direct effect of 5-HT on these organ vessels. Perfusion pressure of the gracilis, skin (hindpaw) and kidneys increased significantly at 43 ± 8, 47 ± 5 and 56, respectively, when 5-HT (200 μg) was injected into the left atrium at a sharp rise in arterial blood pressure ± 27mmHg (P <0.01), while no significant changes of coronary perfusion pressure. After atropine and / or propranolol block m and beta receptors in skeletal muscle, cutaneous and perfused areas, the above effects were absent