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目的:观察芎芷祛风合剂治疗儿童偏头痛的临床效果及安全性,并探讨其作用机制。方法:采用随机分组法将78例偏头痛患儿随机分为两组,治疗组口服芎芷祛风合剂10mL,每日3次;对照组口服盐酸氟桂利嗪胶囊5mg,每晚口服1次,8周为1个疗程。观察芎芷祛风合剂的疗效,并对临床安全性初步观察。结果:治疗组较对照组头痛程度明显减轻,头痛持续时间明显减少,中医证候的改善及总有效率有明显差异(P<0.01)。结论:芎芷祛风合剂可改善偏头痛症状,减少发作次数和缩短发作时间。
Objective: To observe the clinical effect and safety of Xiongzhi Qufeng Mixture in the treatment of migraine in children and to explore its mechanism. Methods: 78 children with migraine were randomly divided into two groups randomly. The treatment group was treated with 10 mL of Xionghu Qufeng Mixture 3 times a day. The control group was treated with flunarizine hydrochloride capsule 5 mg orally once daily , 8 weeks for a course of treatment. Observe the curative effect of Xionghu Qufeng Mixture and preliminary observation of clinical safety. Results: Compared with the control group, the headache in the treatment group was significantly reduced, the duration of headache was significantly reduced, and the improvement of traditional Chinese medicine syndrome and the total effective rate were significantly different (P <0.01). Conclusion: Xiongzhi Qufeng Mixture can improve migraine symptoms, reduce the number of attacks and shorten the attack time.