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幽门螺杆菌(Hp)感染是导致慢性胃炎、消化性溃疡的重要原因,但其发病机制尚不清楚。紧密连接结构和功能受损导致胃黏膜屏障功能障碍在Hp相关性胃病发病中的作用近年来受到关注。紧密连接由多种蛋白及分子组成,包括3种完整的膜蛋白(咬合蛋白、闭合蛋白、连接黏附分子)和1种胞浆蛋白(闭合小环蛋白)。该文主要阐述各种紧密连接蛋白的组成及功能,Hp感染所致紧密连接蛋白功能的变化及其与相关胃病发病的关系,以及增强紧密连接蛋白功能在Hp相关性胃病防治中的意义。
Helicobacter pylori (Hp) infection is an important cause of chronic gastritis and peptic ulcer, but its pathogenesis is not yet clear. In recent years, attention has been paid to the role of gastric mucosal barrier dysfunction in the pathogenesis of Hp-related gastric diseases due to the tight junction structure and impaired function. Tight junctions consist of a variety of proteins and molecules, including three intact membrane proteins (occludin, occludin, connexin) and one cytoplasmic protein (claudin). This article mainly expounds the composition and function of various tight junction proteins, the function of tight junction proteins induced by Hp infection and their relationship with the development of related gastric diseases, and the significance of enhancing the function of tight junction proteins in the prevention and treatment of Hp-related gastric diseases.