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应用抗增殖细胞核抗原（PCNA）的单克隆抗体，以ABC免疫组织化学方法及银染色方法对112例子宫内膜标本进行测定，并与病理学诊断进行对比分析。结果表明：在各种类型的子宫内膜中，PCNA的表达及AgNOR计数依病变的进展明显递增。子宫内膜癌组PCNA表达及AgNOR计数明显高于正常子宫内膜组及子宫内膜增生组（增殖期例外），各组相互比较有显著差异（P＜0．01）。此种方法是测定子宫内膜增生细胞增殖分数的有效手段。对于判断其生物学行为及预后有重要意义，可做为临床判断良恶性子宫内膜增生的指标之一。
Using monoclonal antibody against proliferating cell nuclear antigen (PCNA), 112 cases of endometrial specimens were determined by ABC immunohistochemistry and silver staining, and compared with the pathological diagnosis. The results showed that: in all types of endometrium, PCNA expression and AgNOR count significantly increased in accordance with the progress of the disease. The expression of PCNA and AgNOR in endometrial carcinoma group were significantly higher than those in normal endometrium group and endometrial hyperplasia group (except for proliferative phase), and there was significant difference between each group (P <0.01). This method is an effective measure of proliferative fraction of endometrial hyperplasia cells. To determine the biological behavior and prognosis of great significance, can be used as clinical indicators of benign and malignant endometrial hyperplasia.