2型糖尿病患者发生心脏、大血管病变的危险性是非糖尿病人群的 2～ 5倍。因此早期预测糖尿病大血管病变的发生具有重要临床意义[1] 。目前已经普遍认为微量白蛋白尿的出现预示着糖尿病肾脏病变的发生 ,持续性白蛋白尿的存在是糖尿病肾病进展的标志。近年来大量临床研究结果表明 Diabetes patients with type 2 heart, the risk of macrovascular disease is non-diabetic 2 to 5 times the population. Therefore, early prediction of the occurrence of diabetic macrovascular disease has important clinical significance [1]. It is generally accepted that the presence of microalbuminuria predicts the occurrence of diabetic nephropathy, and the presence of persistent albuminuria is a hallmark of the progression of diabetic nephropathy. In recent years, a large number of clinical studies have shown