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血管内皮祖细胞(endothelial progenitor cells,EPCs)是一种能直接分化为血管内皮细胞的前体细胞,它与出生后的血管形成密切相关,具有重要的病理生理学意义。近年的研究显示EPCs功能受损和数量减少在糖尿病血管病变发生的机制中扮演着重要角色。从单个核细胞移植、内源性EPCs的动员活化以及EPCs的基因修饰这几个方面进行研究,为糖尿病血管病变治疗提供了新思路。本文就EPCs的生物学特性及其与糖尿病血管病变的关系以及内皮祖细胞对糖尿病血管病变治疗的展望进行综述。
Endothelial progenitor cells (EPCs), which are precursors that can differentiate directly into vascular endothelial cells, are closely related to the angiogenesis after birth and have important pathophysiological significance. Recent studies have shown that impaired EPCs function and decreased numbers play an important role in the pathogenesis of diabetic vascular disease. From the transplantation of mononuclear cells, the mobilization and activation of endogenous EPCs and the gene modification of EPCs, this study provides a new idea for the treatment of diabetic vascular disease. This review summarizes the biological characteristics of EPCs and their relationship with diabetic vascular disease and the prospect of endothelial progenitor cells in the treatment of diabetic vascular disease.